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From Human Provocation to CGRP Therapy

Interview with Prof. Jes Olesen

Prof. Jes Olesen: From Human Provocation to CGRP Therapy

A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks.

In this interview with Prof. Jes Olesen, we talk about how the human provocation model was used to test whether calcitonin gene-related peptide (CGRP) could provoke a migraine attack in humans, and how these findings contributed to the development of therapies targeting the CGRP signaling pathway today (e.g., monoclonal antibodies, gepants).