{"id":12592,"date":"2021-12-20T11:45:18","date_gmt":"2021-12-20T11:45:18","guid":{"rendered":"https:\/\/icams2022.com\/?page_id=12592"},"modified":"2021-12-20T12:45:51","modified_gmt":"2021-12-20T12:45:51","slug":"jes-olesen","status":"publish","type":"page","link":"https:\/\/icams2022.com\/index.php\/jes-olesen\/","title":{"rendered":"From Human Provocation to CGRP Therapy"},"content":{"rendered":"<p>[vc_row content_width=&#8221;grid&#8221; css=&#8221;.vc_custom_1481799010187{padding-top: 120px !important;padding-bottom: 120px !important;background-image: url(http:\/\/xpo.edge-themes.com\/wp-content\/uploads\/2016\/12\/page-3-image-6.jpg?id=9758) !important;}&#8221;][vc_column offset=&#8221;vc_col-lg-12 vc_col-md-12&#8243;]<div class=\"edgtf-elements-holder edgtf-responsive-mode-1024\" ><div class=\"edgtf-elements-holder-item edgtf-width-1-1\" data-item-class=\"edgtf-elements-holder-custom-354193\" data-1024-1280=\"0 70px 15px 0\" data-768-1024=\"20px 0px 45px 20px\" data-600-768=\"20px 0px 45px 20px\" data-480-600=\"20px 5px 0 5px\" data-480=\"20px 5px 0 5px\" >\n\t<div class=\"edgtf-elements-holder-item-inner\">\n\t\t<div class=\"edgtf-elements-holder-item-content edgtf-elements-holder-custom-354193\" style=\"padding: 0 77px 6px 0\">\n\t\t\t<div class=\"edgtf-title-section-holder\">\n\t\t\t<h2 class=\"edgtf-title-with-dots\" >\n\t\t\tProf. Jes Olesen: From Human Provocation to CGRP Therapy\t\t<\/h2>\n\t\t<span class=\"edge-title-separator edge-enable-separator\" ><\/span>\n\n\t<\/div>[vc_empty_space height=&#8221;8px&#8221;][vc_column_text]A key feature of migraine is that various factors can trigger an attack, and this phenomenon provides a unique opportunity to investigate disease mechanisms by experimentally inducing migraine attacks.<\/p>\n<p>In this interview with Prof. Jes Olesen, we talk about how the human provocation model was used to test whether calcitonin gene-related peptide (CGRP) could provoke a migraine attack in humans, and how these findings contributed to the development of therapies targeting the CGRP signaling pathway today (e.g., monoclonal antibodies, gepants).[\/vc_column_text][vc_empty_space height=&#8221;35px&#8221;]\t\t<\/div>\n\t<\/div>\n<\/div><div class=\"edgtf-elements-holder-item edgtf-width-1-1\" data-item-class=\"edgtf-elements-holder-custom-111064\"  data-1024-1280=\"0 0 0 0\" data-768-1024=\"0 5px\" data-600-768=\"0 5px\"   >\n\t<div class=\"edgtf-elements-holder-item-inner\">\n\t\t<div class=\"edgtf-elements-holder-item-content edgtf-elements-holder-custom-111064\" style=\"padding: 0 8px\">\n\t\t\t[vc_video link=&#8221;https:\/\/vimeo.com\/658528489\/4abcbca5f4&#8243;]\t\t<\/div>\n\t<\/div>\n<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row content_width=&#8221;grid&#8221; css=&#8221;.vc_custom_1481799010187{padding-top: 120px !important;padding-bottom: 120px !important;background-image: url(http:\/\/xpo.edge-themes.com\/wp-content\/uploads\/2016\/12\/page-3-image-6.jpg?id=9758) !important;}&#8221;][vc_column offset=&#8221;vc_col-lg-12 vc_col-md-12&#8243;][\/vc_column][\/vc_row]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width.php","meta":{"footnotes":""},"class_list":["post-12592","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/pages\/12592","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/comments?post=12592"}],"version-history":[{"count":8,"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/pages\/12592\/revisions"}],"predecessor-version":[{"id":12603,"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/pages\/12592\/revisions\/12603"}],"wp:attachment":[{"href":"https:\/\/icams2022.com\/index.php\/wp-json\/wp\/v2\/media?parent=12592"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}